New anticoagulants in combination with antiplatelet agents.

Anticoagulants versus antiplatelet agents for acute ischaemic stroke.

BACKGROUND Antiplatelet agents produce a small, but worthwhile benefit in long-term functional outcome and survival, and have become standard treatment for acute ischaemic stroke. Anticoagulants are often used as an alternative treatment, despite evidence that they are ineffective in producing long-term benefits. We wanted to review trials which have directly compared anticoagulants and antipla...

New anticoagulants and antiplatelet agents in perioperative period: Recommendations and controversies!

The Role of Combination Therapy with Antiplatelet and Oral Anticoagulant Agents in Cardiovascular Disease

Anticoagulant and antiplatelet agents are indicated in the prevention and treatment of a variety of thromboembolic disorders. Antiplatelet agents predominately effect the development of clot formation in the arterial circulation, where platelets play a more pivotal role than in the venous circulation. Anticoagulants affect clot formation in both the arterial and venous circulation by inhibiting...

Novel anticoagulants in the therapy of peripheral arterial and coronary artery disease.

Anticoagulant and antiplatelet drugs are used and studied in numerous trials for primary and secondary prevention of atherothrombosis since decades. The annual rate for cardiovascular morbidity and mortality is high in patients following an acute coronary syndrome and in patients with peripheral arterial disease (PAD) due to concomitant cardiac and cerebrovascular diseases. Plaque rupture and s...

Review: anticoagulants are not more effective than antiplatelet agents in acute ischemic stroke.

In patients with acute ischemic stroke, what is the comparative effectiveness of anticoagu-lants (alone or with antiplatelet agents) and antiplatelet agents alone given within 14 days of stroke onset? D a t a s o u r c e s Studies were selected if they were randomized controlled trials comparing anticoagulants with antiplatelet agents, or anticoagulants plus antiplatelet agents with antiplatele...